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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS1
All Species:
23.94
Human Site:
T490
Identified Species:
35.11
UniProt:
Q01581
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01581
NP_001091742.1
520
57294
T490
L
V
H
S
N
I
A
T
E
H
I
P
S
P
A
Chimpanzee
Pan troglodytes
XP_517780
610
66491
T580
L
V
H
S
N
I
A
T
E
H
I
P
S
P
A
Rhesus Macaque
Macaca mulatta
XP_001090857
592
65050
T562
L
V
H
S
N
T
A
T
E
H
I
P
S
P
A
Dog
Lupus familis
XP_536483
637
69021
T607
L
V
H
S
S
A
A
T
E
H
I
P
S
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZK9
520
57550
T490
L
V
H
S
N
T
A
T
E
H
I
P
S
P
A
Rat
Rattus norvegicus
P17425
520
57415
T490
L
V
H
S
N
T
A
T
E
H
I
P
S
P
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506375
520
57160
N491
L
A
H
A
S
I
T
N
E
H
I
P
S
P
A
Chicken
Gallus gallus
P23228
522
57541
H491
V
V
H
P
G
I
V
H
E
H
I
P
S
P
A
Frog
Xenopus laevis
NP_001087380
520
57303
N491
S
V
H
S
S
T
A
N
E
H
F
P
S
P
A
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
A478
L
V
S
S
S
M
A
A
E
H
I
P
S
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
L436
P
T
G
S
I
S
A
L
F
P
G
T
Y
Y
L
Honey Bee
Apis mellifera
XP_397202
453
50855
T424
N
C
H
T
V
P
Y
T
P
Q
S
N
I
K
N
Nematode Worm
Caenorhab. elegans
P54871
462
51397
F433
S
L
F
P
N
T
Y
F
L
D
N
M
D
K
L
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
S475
Q
Y
N
R
S
S
V
S
Q
Q
Q
A
V
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
P432
G
I
I
D
L
L
A
P
G
T
Y
Y
L
K
E
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
P462
H
L
K
K
N
F
K
P
Q
G
S
I
E
H
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
87.3
78.6
N.A.
94.6
94.8
N.A.
90.1
83.9
80
77.6
N.A.
58
54.6
38.4
63.2
Protein Similarity:
100
85
87.3
80.5
N.A.
97.5
97.6
N.A.
95.3
91
88.6
87.1
N.A.
69.6
68.6
54.8
75.3
P-Site Identity:
100
100
93.3
86.6
N.A.
93.3
93.3
N.A.
66.6
66.6
66.6
66.6
N.A.
13.3
13.3
6.6
0
P-Site Similarity:
100
100
93.3
93.3
N.A.
93.3
93.3
N.A.
80
73.3
73.3
80
N.A.
13.3
20
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
44
45.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
60.1
60.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
0
7
63
7
0
0
0
7
0
0
57
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
0
0
0
0
7
0
0
7
7
0
% D
% Glu:
0
0
0
0
0
0
0
0
63
0
0
0
7
0
7
% E
% Phe:
0
0
7
0
0
7
0
7
7
0
7
0
0
0
0
% F
% Gly:
7
0
7
0
7
0
0
0
7
7
7
0
0
0
0
% G
% His:
7
0
63
0
0
0
0
7
0
63
0
0
0
7
0
% H
% Ile:
0
7
7
0
7
25
0
0
0
0
57
7
7
0
0
% I
% Lys:
0
0
7
7
0
0
7
0
0
0
0
0
0
19
0
% K
% Leu:
50
13
0
0
7
7
0
7
7
0
0
0
7
0
25
% L
% Met:
0
0
0
0
0
7
0
0
0
0
0
7
0
0
0
% M
% Asn:
7
0
7
0
44
0
0
13
0
0
7
7
0
0
7
% N
% Pro:
7
0
0
13
0
7
0
13
7
7
0
63
0
63
0
% P
% Gln:
7
0
0
0
0
0
0
0
13
13
7
0
0
0
0
% Q
% Arg:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
13
0
7
57
32
13
0
7
0
0
13
0
63
0
7
% S
% Thr:
0
7
0
7
0
32
7
44
0
7
0
7
0
0
0
% T
% Val:
7
57
0
0
7
0
13
0
0
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
13
0
0
0
7
7
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _